Tuesday, 28 February 2012

Argentine hemorrhagic fever


Argentine hemorrhagic fever (AHF) or O'Higgins disease, also known in Argentina as mal de los rastrojos, stubble disease, is a hemorrhagic fever and zoonotic infectious diseaseoccurring in Argentina. It is caused by the Junín virus (an arenavirus, closely related to theMachupo viruscausative agent of Bolivian hemorrhagic fever). Its vector is a species of rodent, the corn mouse.

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[edit]Epidemiology

The disease was first reported in a small place called O'Higgins (Spanish Wikipedia) in Buenos Aires province, Argentina in 1958, giving it one of the names by which it is known.[1] Various theories about its nature were proposed: it was Weil's diseaseleptospirosis, caused by chemical pollution.[1] It was associated with fields containing stubble after the harvest, giving it another of its names.
The endemic area of AHF covers approximately 150,000 km², compromising the provinces of Buenos AiresCórdobaSanta Fe and La Pampa, with an estimated risk population of 5 million.
The vector, a small rodent known locally as ratón maicero ("maize mouse"; Calomys musculinus), suffers from chronic asymptomaticinfection, and spreads the virus through its saliva and urine. Infection is produced through contact of skin or mucous membranes, or through inhalation of infected particles. It is found mostly in people who reside or work in rural areas; 80% of those infected are males between 15 and 60 years of age.

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